Hypertrophic Cardiomyopathy

This tutorial will review the hemodynamic, angiographic, and clinical features of hypertrophic cardiomyopathy and related conditions. Hypertrophic cardiomyopathy is a heterogeneous group of disorders that are characterized by hypertrophy in the absence of physiologic compensation. This condition is an important cause of morbidity and mortality, including sudden death in young people and in athletes. Hypertrophic cardiomyopathy may be obstructive, and associated with significant hemodynamic abnormalities, it may be non-obstructive, or may occur in other patterns such as the apical variant. These patients are often evaluated in the cardiac catheterization laboratory to determine the baseline hemodynamic profile and/or the extent of obstruction. In some patients, treatment with alcohol septal ablation may be appropriate after careful assessment of coronary anatomy, including analysis of the perfusion patterns from the septal perforators of the left anterior descending coronary artery.

You will learn:

  • To describe the various phenotypes of hypertrophic cardiomyopathy, including obstructive and non-obstructive types
  • To correlate the effects of physiologic maneuvers in the differentiation of aortic stenosis and hypertrophic cardiomyopathy
  • To describe the effects of physiologic maneuvers on the cardiac murmur and the associated physiology
  • To recognize the typical hemodynamic findings of hypertrophic cardiomyopathy in the cardiac catheterization laboratory including “spike and dome” patterns and gradients between the left ventricle and the aorta
  • To differentiate true gradient measurements from the common artifacts

Author(s): Michael Ragosta III, MD

Estimated time to complete: 45 minutes

Credit hours: .75

Method and Medium: Learners participate in the interactive learning modules by correctly answering multiple choice questions dispersed throughout. Learners will be prompted to try again if a question is answered incorrectly.

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